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Evolving concepts on regulation and function of renin in distal nephron

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Autor Prieto M.C.
Autor Gonzalez A.A.
Autor Navar L.G.
Fecha Tésis 2013
Fecha Ingreso 2014-04-05T05:42:09Z
Fecha Disponible 2014-04-05T05:42:09Z
Fecha en Repositorio 2014-04-05
dc.identifier 10.1007/s00424-012-1151-6
dc.description.abstract Sustained stimulation of the intrarenal/intratubular renin-angiotensin system in a setting of elevated arterial pressure elicits renal vasoconstriction, increased sodium reabsorption, proliferation, fibrosis, and eventual renal injury. Activation of luminal AT1 receptors in proximal and distal nephron segments by local Ang II formation stimulates various transport systems. Augmented angiotensinogen (AGT) production by proximal tubule cells increases AGT secretion contributing to increased proximal Ang II levels and leading to spillover of AGT into the distal nephron segments, as reflected by increased urinary AGT excretion. The increased distal delivery of AGT provides substrate for renin, which is expressed in principal cells of the collecting tubule and collecting ducts, and is also stimulated by AT 1 receptor activation. Renin and prorenin are secreted into the tubular lumen and act on the AGT delivered from the proximal tubule to form more Ang I. The catalytic actions of renin and or prorenin may be enhanced by binding to prorenin receptors on the intercalated cells or soluble prorenin receptor secreted into the tubular fluid. There is also increased luminal angiotensin converting enzyme in collecting ducts facilitating Ang II formation leading to stimulation of sodium reabsorption via sodium channel and sodium/chloride co-transporter. Thus, increased collecting duct renin contributes to Ang II-dependent hypertension by augmenting distal nephron intratubular Ang II formation leading to sustained stimulation of sodium reabsorption and progression of hypertension. © 2012 Springer-Verlag. en_US
dc.source Pflugers Archiv European Journal of Physiology
Link Descarga dc.source.uri
Title dc.title Evolving concepts on regulation and function of renin in distal nephron en_US
Tipo dc.type Review
dc.description.keywords aldosterone; amiloride; angiotensin 1 receptor; angiotensin II; angiotensinogen; dipeptidyl carboxypeptidase; prorenin; prorenin receptor; protein kinase C; renin; sodium channel; sodium chloride cotransporter; catalysis; disease course; enzyme activity; enzyme localization; enzyme regulation; human; kidney collecting tubule; kidney distal tubule; kidney fibrosis; kidney injury; kidney proximal tubule; nephron; nonhuman; pathophysiology; positive feedback; priority journal; protein expression; protein protein interaction; protein secretion; protein synthesis; receptor binding; renin angiotensin aldosterone system; renovascular hypertension; review; sodium absorption; urinary excretion; vasoconstriction; Angiotensin II; Angiotensinogen; Animals; Humans; Kidney Tubules, Distal; Receptor, Angiotensin, Type 1; Receptors, Cell Surface; Renin; Renin-Angiotensin System; Sodium en_US

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