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Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules

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Autor dc.contributor.author Orellana J.A.
Autor dc.contributor.author Martinez A.D.
Autor dc.contributor.author Retamal M.A.
Fecha Ingreso dc.date.accessioned 2014-04-05T00:18:04Z
Fecha Disponible dc.date.available 2014-04-05T00:18:04Z
Fecha en Repositorio dc.date.issued 2014-04-04
dc.identifier 10.1016/j.neuropharm.2013.02.020
dc.description.abstract Coordinated interaction among cells is critical to develop the extremely complex and dynamic tasks performed by the central nervous system (CNS). Cell synchronization is in part mediated by connexins and pannexins; two different protein families that form gap junction channels and hemichannels. Whereas gap junction channels connect the cytoplasm of contacting cells and coordinate electric and metabolic activities, hemichannels communicate intra- and extra-cellular compartments and serve as diffusional pathways for ions and small molecules. Cells in the CNS depend on paracrine/autocrine communication via several extracellular signaling molecules, such as, cytokines, growth factors, transmitters and free radical species to sense changes in microenvironment as well as to adapt to them. These signaling molecules modulate crucial processes of the CNS, including, cellular migration and differentiation, synaptic transmission and plasticity, glial activation, cell viability and microvascular blood flow. Gap junction channels and hemichannels are affected by different signaling transduction pathways triggered by these paracrine/autocrine signaling molecules. Most of the modulatory effects induced by these signaling molecules are specific to the cell type and the connexin and pannexin subtype expressed in different brain areas. In this review, we summarized and discussed most of the relevant and recently published information on the effects of signaling molecules on connexin or pannexin based channels and their possible relevance in CNS physiology and pathology. This article is part of the Special Issue Section entitled 'Current Pharmacology of Gap Junction Channels and Hemichannels'. © 2013 Elsevier Ltd. All rights reserved. en_US
dc.source Neuropharmacology
Link Descarga dc.source.uri http://www.scopus.com/inward/record.url?eid=2-s2.0-84890425994&partnerID=40&md5=3a9d565771363eb1515f437b8b121b78
Title dc.title Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules en_US
Tipo dc.type Article
dc.description.keywords 4 aminobutyric acid; acetylcholine; adenosine triphosphate; connexin 30; connexin 32; connexin 36; connexin 43; cytokine; dopamine; endothelin; free radical; gap junction protein; glutamic acid; growth factor; hemichannel; membrane protein; neurotransmitter; pannexin; Panx1 protein; serotonin; unclassified drug; adaptation; article; astrocyte; autocrine effect; brain region; cell activation; cell differentiation; cell interaction; cell migration; cell synchronization; cell viability; central nervous system; central nervous system disease; cytoplasm; glia cell; human; microenvironment; microglia; microvascularization; nerve cell; nerve cell plasticity; nonhuman; paracrine signaling; priority journal; protein expression; protein family; regulatory mechanism; signal transduction; synaptic transmission en_US


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