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Enzymatic desymmetrization of prochiral molecules

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Autor dc.contributor.author Palomo J.M.
Autor dc.contributor.author Cabrera Z.
Fecha Ingreso dc.date.accessioned 2014-04-05T00:03:05Z
Fecha Disponible dc.date.available 2014-04-05T00:03:05Z
Fecha en Repositorio dc.date.issued 2014-04-04
dc.identifier 10.2174/157017912803901628
dc.description.abstract Desymmetrization of prochiral compounds is one of the most efficient methods to obtain enantiomerically pure compounds (yield close to 100%); proof of this is its growing application over the last decade in the synthesis of key chiral intermediates used in the preparation of important biologically active compounds. Enzymes are highly specific, enantio- and regioselective catalysts that operate under relatively mild conditions and therefore represent an interesting alternative to chemical methods. This review describes significant progress, particularly from 2006 onwards, in enzymatic desymmetrization of prochiral compounds such as diesters, anhydrides, diamines and diols, where implementation of this strategy has allowed the design of new and improved synthesis routes, establishing it as one of the best alternatives for the preparation of optically active compounds. © 2012 Bentham Science Publishers. en_US
dc.source Current Organic Synthesis
Link Descarga dc.source.uri http://www.scopus.com/inward/record.url?eid=2-s2.0-84876900790&partnerID=40&md5=7b31f0aa348d0a8087a4fc2803dc2cac
Title dc.title Enzymatic desymmetrization of prochiral molecules en_US
Tipo dc.type Review


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